|South Carolina State Line
||South Carolina State Line, About 20 miles south of Rutherfordton, North Carolina, This is where US Route #221 enters North Carolina and begins its north/northeasterly journey, to terminate at Virginia State Line where the highway crosses over to Virginia.
|Bridge over Broad River
||A bridge carries US Route #221 across the Broad River,
|Island Ford Road : Cliffside, NC
||Island Ford Road, to Community of Cliffside, North Carolina, located on the Second Broad River, a tributary of the Broad River in western North Carolina.
|Chase High Road : Henrietta, NC
||Chase High Road, Harries Henrietta Road, Community of Henrietta, North Carolina, Dogwood Valley Golf Club, Community of Caroleen, North Carolina,
|Harris-Henrietta Road : Harris, NC
||Harris-Henrietta Road, Community of Harris, North Carolina, lies just off US Route #221.
|US Rte #74 : Forest City, NC
||US Route #74, Sunnyside Lake, Kingdom Hall-Jehovah's Witness, Rutherford County Offices Tourism Development Authority, Cleghorn Country Club, Green River Plantation located west along US Route #74. To the east lies Alexander Mills, North Carolina, was a town in Rutherford County, North Carolina, is now a part of Forest City, North Carolina. Forest City, North Carolina, formerly known as "Burnt Chimney," a town in Rutherford County, North Carolina, Isothermal Community College,
|Charlotte Road : Spindale, NC
||Junction of NC State Highway 108/US Highway 221
|Green Street : Rutherfordton, NC
||Green Street, Community of Rutherfordton, North Carolina,
|Mountain Street: Chimney Rock State Park
||Junction of US Route #64 & 74A/Mountain Street
|Darlington Road : Lake Brooks
||Darlington Road, to Lake Brooks, a lake lying on the west side of US Route #221.
|Hudlow Road : Union Mills, NC
||Hudlow Road, Community of Union Mills, North Carolina, Center-Intercultural Training,
|Polly Spout Road : Thermal City Gold Mine
||Polly Spout Road, Thermal City Gold Mine, Vein Mountain Road to Structure Number Nineteen Lake, Muddy Creek BSA Lake,
|Intersection : Interstate Hwy #40
||Intersection Interstate Highway #40, Old Fort, North Carolina, well known for its weekly Mountain Music concerts, which draw a large audience and many musicians from the surrounding areas, Old Fort Picnic Area, located in the west along Interstate Highway #40.
|Junction : NC #226
||Junction North Carolina Highway #226, Rutherford Road, to Marion, North Carolina,
|Henderson Street: Marion, NC
|Junction : US Rte #70
||Junction US Route #70, US Route #221 Business, State Route #226, Shiflet Field, Yancey Road, Black Bear Cove,
|Bridge over a River
||A Bridge over a river at this point, carries US Route #221 across,
|Access : Morgan Lake
||Access to, Morgan Lake, a lake located just off US Route #221, within Pisgah National Forest,
|Toms Creek Road : Lake Tahoma
||Toms Creek Road, Lake Tahoma Road/NC #80, Buck Creek Campground & Driving Range, Lake Tahoma, a small reservoir in the mountains of Western North Carolina, in McDowell County, Fishing and recreation allowed on the lake,
|Huskins Branch Road : Toms Creek Falls
||Huskins Branch Road, Toms Creek Falls, a waterfall in the Pisgah National Forest in McDowell County, North Carolina, just west off US Route #221.
|Junction NC #226 : Little Switzerland
||Junction NC #226, Little Switzerland, North Carolina, a community in McDowell and Mitchell counties of North Carolina, located just off the Blue Ridge Parkway, The Switzerland Inn is the only commercial access road on the Blue Ridge Parkway. Church of the Resurrection, was built in 1912, a historic church listed on the National Register of Historic Places,
|Blue Ridge Drive N : Linville Falls Mountain Club
||Blue Ridge Drive N, Linville Falls Mountain Club, a club located just off US Route #221.
||Linville Caverns, a natural rock formation along the Blue Ridge parkway within the Pisgah National Forest,
|NC Rte #183 : Linville Falls, NC
||NC Route #83, Old NC Highway #105, Linville Falls, a waterfall located in the Blue Ridge Mountains of North Carolina, The falls move in several distinct steps, twin set of upper falls, a small gorge, and a high-volume 45 ft drop, located on the Linville River. The Linville Gorge Wilderness, the third largest wilderness area in North Carolina,
|Connector : Blue Ridge Parkway
||Connecting Road to Blue Ridge Parkway, a designated scenic highway, at Linville Falls, North Carolina, Linville Falls Trailer Lodge, Linville Center Rescue Squad, located nearby.
|NC Rte #194 : Three Mile, North Carolina
||North Carolina Route #194, Three Mile, North Carolina, a community in Avery County, North Carolina, Montezuma, North Carolina, a community in Avery County, North Carolina,
|Camp Creek Road / Mattba Road : Linville Falls, NC
||Camp Creek Road, Mattba Road, Linville Falls, North Carolina, an unincorporated community, The community is named after Linville Falls, a nearby waterfall in the Linville Gorge Wilderness.
|Stamey Branch Rd : Plumtree, NC
||Stamey Branch Road, Big Plum Tree Creek Road, Plumtree, North Carolina, an unincorporated community in Avery County, North Carolina, located along US Route #19E.
|Access : Gill State Forest
||Access to, Gill State Forest, a state forest located within the Pisgah National Forest, on the eastern bank of the Linville River,
|Crossnore Drive : Crossnore, NC
||Crossnore Drive, Crossnore, North Carolina, a town in Avery County, North Carolina, Crossnore Presbyterian Church, built in 1924, a historic church listed on the National Register of Historic Places. CA Cannon Jr Memorial Hospital,
|Millers Gap Hwy/NC Rte #194 : Spanish Oak Mountain
||Millers Gap Highway/NC Route #194, Spanish Oak Mountain, a mountain in the North Carolina High Country, lies northwest of this junction, near Newland, North Carolina,
|Junction NC #181 : Pineola, NC
||Junction North Carolina Route #181/Jonas Ridge Highway, Pineola, North Carolina, an unincorporated community in Avery County, North Carolina, Down by the River Campground is located nearby on the bank of Linville River.
|Linville Harbor Pkwy : Land Harbor Lake
||Linville Harbor Parkway, Land Harbor Lake, a lake located just off US Route #221, created by Linville Land Harbor Dam on the Linville River,
|Linville Bypass US #221 : Pixie Mountain
||Linville Bypass US #221, connects with North Carolina Route #181/Newland Highway, Cannon Memorial Hospital Playground, Pixie Mountain, a mountain in the North Carolina High Country, in the community of Linville, The Linville Bypass (NC Hwy #181) runs around Pixie Mountain on its western side. Lake Kawahna lies nearby.
|Roseboro Road : Linville, NC
||Roseboro Road, Linville, North Carolina, a community in Avery County, North Carolina. Grandmother Mountain, a mountain in the North Carolina High Country, near the community of Linville, North Carolina, located within the Pisgah National Forest and next to the Blue Ridge Parkway.
|Junction NC #105 : Grandfather, NC
||Junction NC #105/US #221 Bypass, Brier Knob, a mountain in the North Carolina High Country, Grandfather, a village in Avery County, North Carolina, a fully gated community within Grandfather Golf and Country Club, located along NC #105. Grandfather Lake, a lake located just east of US Route #221.
|Grandfather Mtn Entrance Rd : Grand Father Mountain
||Grandfather Mountain Entrance Road, Grand Father Mountain, a mountain and state park near Linville, North Carolina. It is the highest peak on the eastern escarpment of the Blue Ridge Mountains. Mile High Swinging Bridge,
|Blue Ridge Parkway : Grandmother Gap
||A Connecting Road to, Blue Ridge Parkway, Grandmother Gap, a mountain pass in North Carolina on the Blue Ridge Parkway, near Grandfather Mountain, lies south of this intersection. To the northeast on Blue Ridge Parkway lies, Linn Cove Viaduct, a concrete segmental bridge which snakes around the slopes of Grandfather Mountain in North Carolina.
|Pilot Ridge Road : Coffey Trout Lake
||Pilot Ridge Road, Coffey Trout Lake, a lake located along Edgemont Road,
|Clarence Newton Road : Green Mountain Creek Falls
||Clarence Newton Road, Holloway Mountain Road, to Tanawha Trail, from Beacon Heights, NC to Julian Price, NC. Green Mountain Creek Falls, a water fall located nearby just off US Route #221.
|Johns River Road : Price Lake
||Johns River Road, to Julian Price Memorial Park, a park at the foot of Grandfather Mountain in North Carolina, The nation's largest National Lumberjack Association rally is held here annually at the park on Blue Ridge Parkway. Price Lake,
|Cone Rd : Moses H. Cone Memorial Park
||Cone Road to Blue Ridge Parkway, Shulls Mills Road, The Moses H. Cone Memorial Park, a country estate in Blowing Rock, North Carolina, on the Blue Ridge Parkway, The activities in the park are walking, hiking, cross-country skiing, and horseback riding. Trout Lake,
|Main Street : Blowing Roc, North Carolina
||Main Street, US #321 Business Route, Blowing Rock, North Carolina, a town in North Carolina, Blowing Rock Recreation Office, Blowing Rock City Park, Broyhill Park, lies nearby. Bass Lake, a lake located just north side of S Route #221, in Blowing Rock, North Carolina,
|Junction US #221 Bus. : Blowing Rock
||Junction US #221 Business Route, Valley Boulevard, Chetola Lake, Blowing Rock, a rocky outcropping at the town of Blowing Rock, North Carolina, above a gorge in Caldwell County, in North Carolina, Blowing Rock is private property; a fee for access is payable at the adjacent souvenir shop. The Green Park Inn, a historic hotel, built in 1880s, located on the Eastern Continental Divide in Blowing Rock, North Carolina.
|Intersection : Blue Ridge Parkway
||Intersection of Scenic Blue Ridge Parkway,
|Deerfield Road : Bamboo, NC
||Deerfield Road, to Community of Bamboo, North Carolina, Boone Golf Course, Watauga County Hospital, Appalachian Regional Healthcare System, Watauga County Industrial Fields Complex, Samaritan's Purse, Watauga Village Shopping Center, Boone Heights Shopping Center,
|Junction : NC #105/US #321
||Junction NC #105/US #321, Boone, North Carolina, Flintlock Campground, Appalachian State University, The Mast General Store, a store modeled after the general store concept from the 1800s, located on the west along NC route #194.
|King Street : Boone, NC
|Jefferson Road : Perkinsville, NC
||Jefferson Road, North Carolina Route #194, Community of Perkinsville, North Carolina, Caldwell Community College,
|Bridge over New River
||A bridge spans New River carrying US Route #221 across at Boone, North Carolina,
|Old US 421 S : Triplett, NC
||Old US 421 S, Elk Creek Road, intersects Blue Ridge Parkway, Community of Triplett, North Carolina, Deep Gap, North Carolina, a community located in Watauga County, North Carolina, Powder Horn Mountain, one of the first gated resort communities in Western North Carolina, is located there.
|Junction : US #421
||Junction US Route #421, US Route #421 leaves US Route #221 ending its concurrency and heads southeast towards Wilkesboro, North Carolina, Community of Stony Fork, North Carolina,
|Cranberry Springs Rd : Brownwood, NC
||Cranberry Springs Road, Community of Brownwood, North Carolina, Todd, North Carolina, an unincorporated community, in northwestern North Carolina on the South Fork of the New River, The Todd Historic District, a 19 acre historic district in Todd, North Carolina, is listed on the National Register of Historic Places,
|Idlewild Road : Jump Off Rock
||Idlewild Road, Community of Idlewild, North Carolina, Community of Obids, North Carolina, Jump Off Rock, a high mountain rock on the Blue Ridge mountain range, located along Blue Ridge Parkway, east off US Route #221.
|New River Crossing
||US Route #221 crosses South Fork of the New River over a road bridge,
|Railroad Grade Rd : Fleetwood, NC
||Railroad Grade Road, runs along the New River, Community of Fleetwood, North Carolina,
|Water Tank Road : Lake Ashe
||Water Tank Road, to Lake Ashe, a lake located just off NC Highway #163, northeast of this junction.
|NC #194 : Baldwin, NC
||NC #194, Baldwin Road, Community of Baldwin, North Carolina, Baldwin Community Church,
|Junction : Beaver Creek, NC
||Junction North Carolina Route #163, North Carolina Route #194, Beaver Creek, North Carolina, an unincorporated community in Ashe County, North Carolina, Fairway Ridge Golf Course, West Jefferson, North Carolina a town in Ashe County, North Carolina, Ashe County Public Library, Greenfield Campground, Ashe-Campus Wilkes Community, lies on the east side of US Route #221.
|Mt. Jefferson St Park Rd : Mt. Jefferson State Park
||Mt. Jefferson State Park Road, Mount Jefferson State Park, a state park located Mt. Jefferson, a mountain located in Ashe County, North Carolina, A paved road leads to the mountain's summit.
|Main Street : Jefferson, NC
||Main Street, Jefferson, North Carolina, a town in and the county seat of Ashe County, North Carolina, Ashe Memorial Hospital, Faith Fellowship & Harvest, Kingdom Hall Jehovah's witness, Community of Smethport, North Carolina, lies nearby.
|Junction : NC Rte #88/16
||Junction NC Route #88/16, Community of Wagoner, North Carolina,
|Ashe Central School Rd : Ashe County Airport
||Ashe Central School Road, Ashe County Airport, a public airport located east of Jefferson, North Carolina, Ashelawn Memorial Gardens, North Carolina Highway #16, meets US Route #221 nearby.
|Nathans Creek School Rd : Nathans Creek, NC
||Nathans Creek School Road, Community of Nathans Creek, North Carolina,
|E Shatley Springs Rd : Shatley Springs, NC
||E Shatley Springs Road, Community of Shatley Springs, North Carolina, Crumpler, North Carolina, a community on North Carolina Highway #16 in Ashe County, North Carolina,
|Access : Campground
||US #221 N Acc, Access Road to, a Campground on the New River just off US Route #221.
|Bridge over New River
||At this location, A bridge spanning New River carries US Route #221 across,
|Maines Hill Lane : Scotville, NC
||Maines Hill Lane, Flint Hill Road, Scottville, North Carolina, (formerly, Flint Hill) an unincorporated community in both Ashe and Alleghany Counties, North Carolina, Community of Peden, North Carolina, lies north of US Route #221.
|Intersection : NC Highway #113
||Intersection NC Highway #113, Community of Laurel Springs, North Carolina, lies in the south near the juction of NC #113 with NC route #88 & #18, To the north near the Virginia State Line lies Piney Creek, North Carolina, a community located in Piney Creek Township. Nearby lies New River State Park.
|Walnut Branch Church Rd : Stratford, NC
||Walnut Branch Church Road, Community of Stratford, North Carolina,
|Junction : NC Rte #93
||Junction NC Route #93, to Piney Creek, North Carolina, an unincorporated community located in Piney Creek Township.
|Junction : US Rte #21
||Junction US Route #21, Sparta, North Carolina, Sparta Teapot Museum, Alleghany Memorial Hospital, St. Frances of Rome Catholic, Maxwell Airfield
|Virginia State Line : End of US #221 in North Carolina
||Virginia State Line, on the New River, about 5 miles south of Independence, Virginia, This is where US Route #221 crosses over to Virginia ending its journey through Pisgah National Forest along side scenic Blue Ridge Parkway of North Carolina. New River Campground, a campground on the southern bank of New River near the North Carolina/Virginia State Line lies nearby. -ND11-