||Texas/Oklahoma Border, N670 Road, beside Interstate Highway #40, just west of Texola, Oklahoma, a town in Beckham County, Oklahoma, starts Historic U.S.Route #66 at the Texas State Line.
|Airport Road: Airport
||Airport Road : Shamrock Municipal Airport, a public airport located just north of Interstate Highway #40,
|E12th Street/State Spur 556
||Historic Route #66, diverting from Interstate Highway #40, travels on E12th Street/State Spur 556 to Shamrock, Texas,
||Junction United States Route #83, Shamrock, Texas, a city in Wheeler County, Texas, Old Motel, Tower Station (U-Drop Inn), and other buildings of Historic Route 66 era, are located along the Route here. Shamrock General Hospital, Red Rock River flows off Interstate Highway #40. Wheeler, Texas, a city in Wheeler County, Texas, lies north on U.S.Route #83.
||Farm to Market Road 1547, Community of Lela, Texas a small town with few inhabitants located on Interstate Highway #40. Community of Dozier, Texas lies few miles south on Farm to Market Road 1547.
|Farm to Mrkt Rd 453: Magic City, TX
||Farm to Market Road 453 / County Road 6, Hrnciar Lake, Machina Lake, Community of Magic City, Texas, Lake Loraine,
|Co Line Road
||Take a right turn to switch to the other side of the Interstate Highway #40 Service Road, to continue driving on Historic Route, County Line Road, and take a left turn on to the I-40 Service Road to drive on Historic Route #66 to McLean, Texas,
||A right turn on Spur 555 / 1st Street to drive on Historic Route #66, to McLean, Texas.
|Main Street: McLean, TX
||Main Street, McLean, Texas, a town in Gray County, Texas, Devil's Rope Museum, McLean Alanreed Area Museum. Historic Route #66 passes through the town of McLean, Texas on 1st Street/Spur 555.
|Interstate Hwy #40
||A left turn on to 26 Road, and another left turn to join the Interstate Highway #40 Service Road on the southern side of the I-40, which was the route of Historic U.S.Route #66.
||Historic Route runs on Farm to Market Road 291, 3rd Avenue, in Alanreed, Texas, a community in Gray County, Texas,
|2477 Road : National Grassland
||Farm to Market Road 2477, to McClellan Creek National Grassland, lies north of here.
|Junction : Jericho, Texas
||Junction Texas Highway #70, Community of Jericho, Texas. Howardwick, Texas, a city in Donley County, Texas, Greenbelt Reservoir, located south along Texas Highway #70.
|Boydston Road: Boydston, TX
||Boydston Road, County Road 5, Community of Boydston, Texas,
|I-40 Business Route: Groom, TX
||Interstate Highway Business Route #40, runs on Old Historic Route #66 which runs through Groom, Texas.
|Co Road CC: Groom, TX
||County Road CC, Groom, Texas, a town in Carson County, Texas, An abandoned Motel along the Old Historic Route #66, Groom Library, United Methodist Church, A large cross adjacent to Interstate Highway #40 By-pass road, located here in Groom, Texas along the Historic Route #66.
|Ranch Road 294: Goodnight, TX
||Ranch Road 294 / Farm to Market Road 294, Goodnight, Texas, a community in Armstrong County, Texas, White Deer, Texas, a town in Carson County, Texas, lies north off Interstate Highway #40,
|Junction TX Hwy #207
||Junction Texas Highway #207, Historic Route #66 here travels on Texas Highway #207 straight westward leaving Interstate #40 to rejoin later after a few miles west. Claude, Texas, a city in Armstrong County, Texas, located south on Texas Highway #207.
|Interstate hwy #40
||Historic Route #66 runs alongside Interstate Highway #40, switching from Farm to Market Road 2161.
||Farm to Market Road 2373, Community of Yamall, Texas,
|Farm to Markt Road 2575: Air Force Base
||Historic Route #66 continues its run on Farm to Market Road 2575 to Amarillo Air Force Base, originally Amarillo Army Air Field, a former United States Air Force base located in Potter County, Texas, East of downtown Amarillo, Texas.
|Avenue B/NE 8th Avenue
||Take a right turn from NE 8th Avenue on to Avenue B, continue straight on B Avenue until the Road connects with United States Highway #60/E Amarillo Boulevard, where take a left turn to continue driving on Historic Route #66.
||Take a left turn on to U.S.Route #60/Interstate Hwy #40, to Amarillo, Texas,
|Intersection Texas Hwy #335
||Intersection Texas Highway #335, N Lakeside Drive, Big Texan Steak Ranch, Kwahadi Heritage, Rick Husband Amarillo International Airport/Airport Amarillo International,
|N Taylor Street : Amarillo, TX
||Historic Route #66 takes a Left Turn on N Taylor Street, in Amarillo, Texas, Wonderland Amusement Park, lies along United States Highway #287/87 north of here. Thompson Memorial Park, Ross Rogers Golf Course,
||Historic Route #66 turns right on to 6th Avenue and takes a right turn on Bushland Boulevard/Texas Route #279, just before connecting with Interstate Highway #40/W Amarillo Boulevard. Amarillo, Texas, the 15th-largest city in Texas, The Amarillo Civic Center, a multi-purpose convention center in Amarillo, Texas. The Santa Fe Building, one of the oldest buildings in downtown Amarillo, Texas, Chase Tower is a 31-story building and was formerly known as SPS Tower and Bank One Center. It is the tallest structure in Amarillo and the West Texas region. Amarillo Public Library, Globe News Center for the Performing Arts
|S Western Street: Park
||S Western Street, Sam Houston Park, Amarillo Country Club, Amarillo Fellowship Church, Tascosa Country Club, Hastings Store Support Center, Western Plaza Shopping Center,
||Junction Interstate Highway #40, Historic Route #66 turns left on to W.Amarillo Boulevard/I-40, Northwest Amarillo Public Library, Amarillo College West Campus, Baptist St. Anthony Panhandle Surgery, Northwest Texas Rehabilitation Hospital, located west along 9th Avenue.
|S Soncy Road/Texas Route #335
||S Soncy Road / Texas Route #335, Westgate Shopping Center, Southwest Park, Bishop Hills, Texas, a town in Potter County, Texas, Wildcat Bluff Nature Center, located north on N Soncy Road.
|Hope Road: Cadillac Ranch
||Hope Road, to Cadillac Ranch, a public art installation and sculpture in Amarillo, Texas, It consists of what were either older running used or junk Cadillac automobiles, representing a number of evolutions of the car line,
||Main Street, Wildorado, Texas, a community in Oldham County, Texas, located on the Historic Route #66,
||Access to, Oldham County Airport, located along Interstate Highway #40, east of Vega, Texas. Historic Route #66, runs through the city of Vega, Texas, on the course of Business Route I-40,
|Main Street: Vega, TX
||Main Street/United States Route #385, Vega, Texas, a city in Oldham County, Texas, Boot Hill Saloon, A Texaco Service Station (now abandoned), located along the Historic Route in Vega, Texas.
|Grand Avenue: Adrian, TX
||Grand Avenue, Adrian, Texas, a city in Oldham County, Texas, The famous Mid Point Cafe, an icon on Historic Route 66, in Adrian, Texas, which claims to be the Midpoint between Los Angeles, CA and Chicago, IL, located nearby.
||Interstate Highway #40 Service Road, County Road 18, Community of Gruhikey, Texas.
||A Rest Area, located on the Interstate Highway #40, and the Old Historic Route #66.
|Access Road: Boise, TX
||Access Road to, Boise, Texas, a ghost town in Oldham County, Texas, lies south of Interstate Highway #40,
||A left turn to cross to the other side of the Interstate Highway #40, near Glenrio, Texas, An Abandoned Sinclair filling station on Historic Route #66 is located here.
|Texas/New Mexico Border
||Texas/New Mexico Border, at Glenrio, Texas, a community in both Deaf Smith County, Texas, and Quay County, New Mexico, located on Route 66, lies on the Texas/New Mexico state line. This is where the Texas part of the Historic Route #66 ends.