||Junction State Highway #125 with State Highway #905 in Otay Mesa, California, east of Brownfield Municipal Airport, just north of United States/Mexico border. This is where California State Highway #125 starts its run to end at a junction with State Route #52 in Santee, California.
||Birch Road, Mater Dei Catholic High School, a private, Roman Catholic high school in Chula Vista, California, located in the Roman Catholic Diocese of San Diego. Otay Ranch Town Center, located along State Route #125,
||Intersection Olympic Parkway, Lower Otay Lake, Otay County Open Space Preserve, Lower Otay Lake Dam, Otay Lake County Park, Sharp Chula Vista Medical Center,
||Intersection Otay Lakes Road, Chula Vista Community Park, Southwestern College, a public community college located in the city of Chula Vista, California, Chula Vista, California, a city in San Diego County, California, Eastlake Greens Golf Course, Lower Otay Lake, Skydive at San Diego Airport located along Otay Lakes Road, east of Lower Otay Lake,
|E H Street/Proctor Valley Road
||E H Street/Proctor Valley Road, Upper Otay Lake, located on the east of California State Highway #125, Rancho Del Rey Shopping Center, lies on the west of the Highway in Chula Vista, California
|Summit Meadow Road: Summit Site
||Summit Meadow Road, Sweetwater County Park, Summit Site, located just off California State Highway #125, on the western shore of Sweetwater Reservoir,
|Junction : Park
||Junction California State Route #54, Sweetwater Road/County Highway S17, Sweetwater Regional Park, Bonita, California, a community in San Diego County, California,
|Exit 12/Sweetewater Road
||Exit 12/Sweetwater Road, S Bay Freeway, State Route #17/54, Spring Valley County Park, La Presa, California, a neighborhood in the community of Spring Valley in San Diego County, California, Sweetwater Reservoir, Boone Neighborhood Park, Paradise Valley Park and Recreation Center,
||Jamacha Road, Apple Street, Truth Apostolic Community Church, Sweetwater Lane Comunity Park, in the neighborhood of La Presa, California,
||Junction California State Route #94/Martin Luther King Jr. Freeway, Market Place at the Grove Shopping Center, Webster, California, a neighborhood of the Southeast region of San Diego, California. Gateway, California, a neighborhood of the Mid-City region of San Diego, California.
|Junction: State Route #94
||Junction State Route #94/Martin Luther King Jr. Freeway, Rancho San Diego Village Shopping Center, Spring Valley, California, a community in San Diego County, California, Hubert H. Bancroft Ranch House, a historic structure in Spring Valley, California. It is the first Anglo-American structure in Spring Valley, a National Historic Landmark.
||Lemon Avenue, Mount Helix Reservoir, Casa de Oro-Mount Helix, California, a community in San Diego County, California, La Mesa, California, a city in San Diego County, California, La Mesa Springs Shopping Center,
|Intersection: Interstate Highway #8
||Intersection of Interstate Highway #8
||Amaya Drive, Fletcher Parkway, Harry Griffin Regional Park, Grassmont Reservoir, Alavarado Parkway Institute,
||Navajo Road, Fletcher Parkway, San Carlos Golf Course, Mission Trails Golf Course, San Carlos Shopping Center, Eagle Ridge Drive, Cowles Mountain, a prominent hill within the city limits of San Diego, California and also within Mission Trails Regional Park. The main trail to the summit is a popular hiking destination, A breath-taking 360 degree panorama view of San Diego County is offered from the summit.
|Grossmont College Drive
||Grossmont College Drive, Fletcher Hills Open Space, Grossmont College, Grossmont-Cuyamaca Community College, Weld Boulevard, to, Gillespie Field, a public-use airport located northeast of San Diego, in El Cajon, San Diego County, California, East San Diego Co Fairgrounds,
|Junction of State Route #52
||Community of Santee, California, San Diego County, East of Mission Trails Regional Park, a open space preserve within the city of San Diego, California, and east of The Old Mission Dam, located in San Diego, California.