Nature trails, quite walkways, scenic overlooks Slow down and enjoy this part of your drive. There are several opportunities to pull over,get out of the car, and enjoy the mountains. I-40 (exit 407) to the Great Smoky Mountains Please note: As this is the most traveled route to the Smoky Mountains from the Knoxville area, for the first 13 miles of this highway you will be traveling Tennesse State Route 66. At Sevierville this route now becomes US Route 441. Have a safe trip!