Exit #101 Interstate #90 - City of Missoula NOTE: Highway #200 overlaps Interstate Highway #90 at this point east. City of Missoula, nestled in the Rockies of Western Montana is one of America's most sophisticated small towns-Missoula. With an area population of more than 75,000, Missoula has what you'd expect to find in a big city. Missoula is surrounded by millions of acres of National Forest, wilderness and recreation areas. Montana, from skiing to, sailing to snowmobiling, wildlife watching to golfing, fishing to hiking, whitewater rafting to just relaxing and taking in the scenery, there are a plethora of activities to keep you busy as long as you care to stay.