City of San Luis Obispo, California Junction of Highway #101. South to cities of Pismo Beach, Lompoc, Santa Barbara. North to San Fransisco. California Pacific Coast Highway This coastal highway winds along some of the most spectacular ocean views in the U.S. The highway contains countless examples of the many intrinsic qualities that make a highway a National Scenic Byway--qualities like perfect views of ocean waves breaking on rocky shorelines and cliffs, dozens of historical landmarks like Spanish Missions and Spanish settlements.